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High molecular weight polyethylene oxides (PEOs) have recently been proposed as an alternative to hydroxypropylmethylcellulose (HPMC) in controlled release matrix tablets. In this study, we compared the performance of PEO and HPMC polymers when employed in the Geomatrix technology, a versatile, well-known method to achieve extended release of drugs at a constant rate. Four core formulations were prepared, containing a soluble drug (diltiazem) and, alternatively, PEO or HPMC of two different viscosity grades. These formulations have the same composition except for the polymer employed. Similarly, four barrier formulations were also prepared, which only differ in the kind of polymer employed. Three-layer Geomatrix systems were then prepared using these core and barrier formulations. The release profiles of the different three-layer systems obtained were compared, to verify if PEO could efficiently replace HPMC in this type of dosage form. The results show that slower release rates can be obtained from the plain matrices containing HPMC compared to PEO, moreover HPMC, used in the barrier formulations, is generally more efficient in controlling drug release rate in three-layer Geomatrix systems.
Product Details
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Hydroxypropyl methylcellulose
HPMC is a highly pure cotton cellulose as raw material, under alkaline conditions by special etherification and preparation.White or whitish powder.HPMC decreases with the decrease of methoxide content, increase of gel point, decrease of water solubility and decrease of surface activity.
HPMC has thickening ability, salt resistance, low ash powder, pH stability, water retention, dimensional stability, excellent film forming, and a wide range of enzyme resistance, dispersion and adhesion.
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Our Company
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Hebei Yibang construction materials Co., Ltd
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main production and operation:
Hydroxypropyl methylcellulose
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hydroxylomethylcellulose
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Latex powder series
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Polypropylene fiber
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The company has passed ISO- international quality system certification
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The product specifications are complete and the supply is sufficient. High quality products and preferential prices have won the praise of customers, with good reputation.
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Our service
Packing: In 25kg bags out HDPE bags inner with LDPE bagsStore it in a cool, dry place below 30degree and protected against humidity and pressing, since the goods is thermoplastic, storage time should not exceed six months.Quantity/20GP:12Tons with pallets,14tons without pallets.Quantity/40GP:24Tons with pallets ,28tons without pallets.1. Cement mortar: Improve the dispersion of cement-sand, greatly improve the plasticity and water retention of the mortar, and have an effect on preventing cracks, which can enhance the strength of the cement.2, tile cement: improve the plasticity, water retention of the pressed tile mortar, improve the bonding strength of the tile, prevent powdering.3, asbestos and other refractory coating: as a suspension agent, fluidity improver, but also improve the adhesion to the substrate.4, gypsum coagulation slurry: improve water retention and processability, improve the adhesion to the substrate.5. Joint cement: added to the joint cement for gypsum board to improve fluidity and water retention.6. Latex putty: Improve the fluidity and water retention of putty based on resin latex.7. Stucco: As a paste instead of natural material, it can improve water retention and improve the bonding force with the substrate.8. Coating: As a plasticizer for latex paint, it has an effect on improving the handling properties and fluidity of paints and putty powder.9. Spray coating: It has good effect on preventing the cement or latex coating from sinking and improving the fluidity and spray pattern.10. Cement and gypsum secondary products: used as an extrusion molding binder for hydraulic materials such as cement-asbestos, which improves fluidity and provides uniform molded articles.11. Fiber wall: It is effective as a binder for sand walls due to its anti-enzyme and antibacterial action.12. Others: It can be used as a bubble retaining agent (PC version) which acts as a thin clay mortar and a mud hydraulic operator.Based on the principle of "customer first, quality first", the company has established and improved the strict quality standard inspection system. In addition to the ISO certification system, the company also commissioned SGS testing and testing institutions to test the quality of our products with national standards as the benchmark, we do our best to satisfy our customers with our quality.
1. We provide life-long after sale service.
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3. All enquiries and requests about our products will be replied within 24 hours except weekends and public holidays of China.
4. All problems faced by our customers will be taken and solved promptly.
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1.Q:Are you a factory or trading company?
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2 Q: What documents you provide?
A: Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.PLS let us know if your markets have any special requirements.
3 Q: What is loading port?
A: Our factory is nearby Tianjin Port, but loading port can be negotiated.
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If you want to learn more, please visit our website HPMC for building materials|CAS -65-3.
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